Scientific Journal of KubSAU

Polythematic online scientific journal
of Kuban State Agrarian University
ISSN 1990-4665
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Name

Grankina Anastasiya Olegovna

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South Federal University
   

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Articles count: 5

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131 kb

CLINICAL AND MORPHOLOGICAL FACTORS AND PREDICTION PARAMETERS OF CELL CYCLE IN ESOPHAGEAL CANCER

abstract 1241610028 issue 124 pp. 484 – 493 30.12.2016 ru 108
The aim of the study is to compare the traditional clinicopathologic factors and prognosis of cell cycle parameters, such as ploidy, cell cycle kinetics, as well as the study of DNA content in the tumor tissue of patients with esophageal cancer. Cancer of the esophagus - a very aggressive malignant disease, most commonly manifested impaired swallowing. As a rule, this type of cancer pathology is characterized by unfavorable outcome. Ploidy and cell proliferation activity, defined by the content of the DNA of the tumor - synthesizing cells are one of the important indicators of the growth rate of malignancy and prognosis. The study was performed on tumor tissue fragments of the 30 patients operated on for cancer of the esophagus. DNA study - conducted in the open cell material aftercare. DNA cell content was determined by flow cytometry BD FACSCanto II. By studying the DNA-cytometric parameters, we found the prevalence of aneuploid tumors in 66.7%. It was shown that DNAcytometric parameters are independent of gender. Major weight of diploid and aneuploid cell tumors of the esophagus was in G0 / 1 phase of the cell cycle. Comparative analysis of DNA - cytometric parameters and the degree of differentiation of esophageal tumor revealed a prevalence of aneuploid tumors in all the test cases. content distribution pattern of tumor cells was found in the G0 / G1-, G2 + M -, S - phase of the cell cycle at different stages of the disease
165 kb

HIFU: PROSPECTS OF APPLICATION IN ONCOUROLOGY

abstract 1221608019 issue 122 pp. 264 – 277 31.10.2016 ru 153
Prostate cancer (PC) is one of the most frequently malignant neoplasms in the worldwide male population. Back in the 90's began a promising noninvasive method of high-intensity focused ultrasound (HIFU) as an alternative to radical prostatectomy for the treatment of localized prostate cancer was used. Information about the destructive histological effect by HIFU has been known since the 1930, however, the clinical implementation of this technology due to the absence at the time visualization capabilities for monitoring during the procedure has been postponed. In this paper, an overview of published data on the HIFU clinical application in prostate cancer as a major, "saving" and focal therapy. Examples of a favorable combination of this method are also provided with pharmacological agents. Based on the analysis of clinical data, we can say that HIFU is a good alternative minimally invasive therapeutic modality for patients with prostate cancer who are not candidates for radical prostatectomy. Applying of HIFU is possible as a treatment option with local recurrence after external radiotherapy, with careful selection of patients is important, depending on prognostic factors
2178 kb

INFLUENCE OF MALIGNIZATIONS LEVEL OF ASTROCYTIC HUMAN BRAIN TUMOR ON THE EXPRESSION OF CONNEXIN-43

abstract 0931309044 issue 93 pp. 644 – 656 30.11.2013 ru 731
Study was performed on 12 samples of astrocytic human brain tumors, which differ by the level of malignancy and histological indications. The study was conducted with the method of immunohistochemistry using a commercially available antibody anti-connexin-43 (Cx 43), a prior test of which was carried out on myocardium tissue of rats (positive control). The study showed that with the increasing of malignant level of astrocytomas, there was marked the decreased level of connexin-43 expression of, which is apparently to be associated with the destruction of intercellular gap junctions in tumor tissue
141 kb

THE COMPARATIVE CHARACTERISTICS OF CTCs IN COLORECTAL CANCER PATIENTS DEPENDING ON THE CHOICE OF SURGICAL INTERVENTION

abstract 1221608073 issue 122 pp. 1064 – 1074 31.10.2016 ru 166
Mortality from malignant diseases is directly linked to early metastasis and relapse. It is now possible to identify individual tumor cells in bone marrow biopsies and peripheral blood. Colorectal cancer is one of the leading places in the structure of cancer incidence and mortality, both in Russia and around the world. Studies have shown that after surgery the ability of tumor cells to the dissemination and implantation increases. The work contains 30 patients with the verified colorectal cancer with metastasis to the liver. To determine the CSC we have applied an analysis technology in CellSearch System ™ (Janssen Diagnostics, LLC). Our study of the number and frequency of detection of circulating tumor cells in peripheral blood of patients and control group demonstrates the reduction in the number of CTCs during laparoscopic surgery and changing the dynamics of the level of tumor cells in the form of reduction from the stage of the mobilization of the drug due to minimally invasive access, minimizing manipulation in the projection of the tumor and as a consequence, preventing the release into the blood stream of single tumor cells
868 kb

THE ROLE OF GAP JUNCTIONS IN THE DEVELOPMENT OF ASTROCYTIC HUMAN BRAIN TUMOR

abstract 1051501028 issue 105 pp. 472 – 490 30.01.2015 ru 542
Recently, much attention is paid to research the role of cell-cell interactions by gap junctions in the process of malignant transformation and mechanisms of antitumor resistance. Meanwhile, the greatest interest is astrocytic tumors. Depending on the degree of malignancy, astrocytomas are divided into: pilocytic astrocytoma (Grade I), subependymal giant cell astrocytoma (Grade I), pleomorphic xanthoastrocytoma (Grade II), diffuse astrocytoma (Grade II), anaplastic astrocytoma (Grade III), glioblastoma (Grade IV ) gliomatosis cerebri (Grade IV). Information of literature devoted to astrocytic tumors (gliomas) - the most common brain tumor in large part obtained in studies in cell cultures and different contradictions. Along with data on the reduction of glial tumors cells communicability through GJ, there is evidence of an opposite character - a functionally active GJ in gliomas and inhibition of tumor growth by reducing intercellular communicability by GJ. However, up to now there have been no studies of the effect and function of hemichannels in cancer cells, which would provide detailed information on: 1) the characteristic of presence and relative abundance of hemichannels in cancer cells; 2) evaluation of absorption / release of hemichannels mediated molecules in tumor cells than in non-tumor cells; 3) functional consequences of activation and blocking of hemichannels in tumor cells and 4) the prognostic value of the expression / activation of hemichannels in human malignancies
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