Scientific Journal of KubSAU

Polythematic online scientific journal
of Kuban State Agrarian University
ISSN 1990-4665
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Name

Lifentsova Mariya Nikitichna

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Honorary rank

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Kuban State Agrarian University
   

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lifentsova.marya@yandex.ru


Articles count: 5

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145 kb

DETERMINATION OF ACUTE TOXICITY OF ROKSATSIN

abstract 1211607124 issue 121 pp. 1975 – 1984 30.09.2016 ru 83
In this article, the authors have defined the acute toxicity of Roksatsin preparation, which represents a 20 % aqueous solution of polyhexamethylene guanidinehydrochloride (PHMG). The acute toxicity of Roksatsin in the first series of experiments was studied on white mice upon intragastric administration. In the second series of the experiments, Roksatsin was administered subcutaneously to white rats and in the third series of experiments the preparation was administered intracisternally to cows. The results of the first series of experiments showed that Roksatsin by the internal method of appointment is slightly toxic to white mice. In this experiment not been a single case of acute intoxication and death of animals. Experiments to determine the acute toxicity of the preparation for white rats were performed in triplicate. In the first series of experiment, the LD50 was 4.8 ml/kg. It is found, that the calculated coefficients LD50 for other two series were close to the first one: the second - 4.2 ml/kg and the third - 4.5 ml/kg. Therefore, the authors found that the Roksatsin preparation upon subcutaneously administration according GOST 12.1.007-76 is a low-toxic compound (4th class of danger). As a result of the third series of the experiments, it was found that the intracisternally administration of Roksatsin preparation to cows in a dose of 5 ml is not toxic to the animal organism. Intracisternal administration of Roksatsin does not have a significant impact on the morphological and biochemical indices of blood. On this basis, Roksatsin preparation with different routes of administration is low-toxic and it can be recommended for clinical researches
183 kb

EFFICIENCY OF ROKSATSIN IN AEROSOL DISINFECTION OF THE LIVESTOCK BUILDINGS

abstract 1211607125 issue 121 pp. 1985 – 1994 30.09.2016 ru 81
The authors briefly describe the properties of polyhexamethyleneguanidine hydrochloride (PHMG), which refers to a broad-spectrum biocide and has antimicrobial activity against Gram-negative and Gram-positive bacteria, viruses and fungi. PHMG has a deodorizing effect, gives the treated surfaces long bactericidal effect, which can be stored depending on the surface and other external factors from 3 days to 8 months. The authors have presented data about the level of bacterial and fungal contamination of air in the dispensary before and after aerosol treatment of Roksatsin. Bacterial contamination of air dispensary determined via the sedimentation method (Koch Method), which is settling microflora (in air), under gravity, on the surface of a growth medium. For the determination of total bacteria and fungi in 1m3 of air the authors make calculations of total aerobic microbial count (TAMC) according to the formula that was proposed by V.L. Omelyanskii. Bacterial contamination of air was evaluated before disinfection. Accounting quality of aerosol disinfection performed by sedimentation microflora on Petri Dishes through 30, 60 and 120 minutes of exposition. In the analysis of the data the authors defined that Roksatsin as a disinfectant has a negative effect on pathogens, namely significantly reduced the content of pathogenic and conditionally pathogenic bacteria and fungi in the air, so it can be used for preventive and compelled aerosol disinfection of air in the livestock buildings
186 kb

FACTORS CONTRIBUTING TO THE EMERGENCE OF FUNCTIONAL DISORDERS OF BIRTH-GENITAL APPARATUS AT COWS

abstract 1211607113 issue 121 pp. 1818 – 1827 30.09.2016 ru 74
ЖИВОТНОВОДСТВО, КРУПНЫЙ РОГАТЫЙ СКОТ, ДИСФУНКЦИЯ ЯИЧНИКОВ, ЭНДОМЕТРИТ, БЕСПЛОДИЕ, СУБИНВОЛЮЦИЯ МАТКИ, ПОЛОВОЙ ЦИКЛ, ПЕРСИСТИРУЮЩЕЕ ЖЕЛТОЕ ТЕЛО, КИСТА ЯИЧНИКОВ, ГОРМОНЫ
143 kb

PRECLINICAL STUDIES OF PHARMACOLOGICAL PROPERTIES OF A NEW DRUG URITOSOM FOR THE TREATMENT AND PREVENTION DISEASES OF GENITOURINARY SYSTEM

abstract 1241610056 issue 124 pp. 852 – 861 30.12.2016 ru 148
In this study, the authors have defined the acute, subchronic and chronic toxicity of Uritosom preparation, and also its skin-irritating and sensitizing action. The studies that determined the acute toxicity of the drug Uritosom found that remedy which intended for the treatment and prevention of diseases of the genitourinary system with internal method of appointment during the entire observation period did not cause the death and acute toxicity in laboratory animals. In the study of subchronic and chronic toxicity of the drug Uritosom throughout the observation period in both experimental groups death and acute intoxication in animals not registered, also there were no negative phenomena in behavior, reflexes were saved. Consequently, the preparation according to the degree of impact on the body of warm-blooded animals refers to low-hazard substances (4th class of hazard according to GOST 12.1.007-76). Study of the irritant action of Uritosom preparation was carried out in two series of experiments. In the first series of experiments was determined irritating action by conjunctival swab sampling method, in the second - by skin application. The study of the sensitizing action of the drug was determined by the method of maximum sensitizing effects. The authors have found that the preparation has no irritating and sensitizing effect on the tissue in its application zone. On this basis, Uritosom preparation at different ways of application is low-toxic and it can be recommended for clinical research
284 kb

USE OF FLUCONAZOLE FOR TREATMENT OF CHRONIC ENDOMETRITIS AT COWS

abstract 1241610057 issue 124 pp. 862 – 874 30.12.2016 ru 147
That article is of interest to practicing veterinarians. Currently, the biggest obstacle in the development of dairy farming is infertility at cows, which is caused by the presence of diseases of the reproductive organs, most of which is occupied by acute and chronic endometritis. The frequency of occurrence of chronic endometritis at cows reaches high levels, from 10 to 66.3%, averaging 14%. One of the direct causes of chronic endometritis is association of pathogenic and opportunistic microorganisms and fungi. Many chemotherapeutic agents which are designed for prophylaxis and treatment of acute postpartum endometritis do not give a high therapeutic effect in the treatment of chronic endometritis or amount and frequency of application drugs is very high. Analyzing the data, the authors developed a new drug which has fungicidal and antibacterial actions - Florinazol. The experiments showed that the use the Florinazol preparation in combination with myotropic, pathogenetic and vitamin preparations gives 90% of therapeutic efficiency, while the frequency of administration of the drug was on average 3 fold, and the duration of treatment was 5 days
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