Scientific Journal of KubSAU

Mortality from malignant diseases is directly linked to early metastasis and relapse. It is now possible to identify individual tumor cells in bone marrow biopsies and peripheral blood. Colorectal cancer is one of the leading places in the structure of cancer incidence and mortality, both in Russia and around the world. Studies have shown that after surgery the ability of tumor cells to the dissemination and implantation increases. The work contains 30 patients with the verified colorectal cancer with metastasis to the liver. To determine the CSC we have applied an analysis technology in CellSearch System â„¢ (Janssen Diagnostics, LLC). Our study of the number and frequency of detection of circulating tumor cells in peripheral blood of patients and control group demonstrates the reduction in the number of CTCs during laparoscopic surgery and changing the dynamics of the level of tumor cells in the form of reduction from the stage of the mobilization of the drug due to minimally invasive access, minimizing manipulation in the projection of the tumor and as a consequence, preventing the release into the blood stream of single tumor cells