Scientific Journal of KubSAU

Polythematic online scientific journal
of Kuban State Agrarian University
ISSN 1990-4665
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Name

Piven Aleksandr Vladimirovich

Scholastic degree

Academic rank

Honorary rank

Organization, job position

Children's city clinical hospital №1
   

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Articles count: 2

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299 kb

NON-INVASIVE DIAGNOSTICS OF ANEUPLOIDY OF A FETUS WITH CIRCULATING TROPHOBLAST CELLS IN MATERNAL BLOOD

abstract 1231609131 issue 123 pp. 1965 – 1984 30.11.2016 ru 494
Isolation of fetal cells from the blood of a pregnant woman is more relevant for receiving the information of the genome of a fetus and implementation in clinical practice, non-invasive screening methods for prenatal diagnosis. The work proposes efficient ways of sorting trophoblasts circulating in maternal blood for the diagnosis of fetal aneuploidy in early gestation by analyzing microsatellite marker of the chromosomes that most prone to numerical aberrations (13, 18, 21, X and Y). A set of microsatellite markers allowed to reveal aneuploidy in three pregnant women, and also to exclude mosaicism and contamination of samples with maternal cells. A retrospective analysis of data on invasive cytogenetic studies (chorionic villus sampling) confirmed the results of the study
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THE POSSIBILITY OF THE DETERMINATION OF SINGLE NUCLEOTIDE POLYMORPHISMS AND HLA-GENOTYPING OF EMBRYONES ON THE BASIS OF THE GENETIC MATERIAL OF THE BLASTOMERES IN THE PROGRAMS OF PREIMPLANTATION SCREENING

abstract 1341710008 issue 134 pp. 99 – 114 29.12.2017 ru 161
The research shows the possibility of extended preimplantation genetic screening (PGD) that allows to improve the strategy of selection of embryos that satisfies not only the requirement of the absence of chromosomal abnormalities, but also includes their additional check for predisposition to various diseases, as well as the choice of the embryo with the most optimal HLA haplotype in cases with expressed compatibility of parents for HLA-genes
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