Scientific Journal of KubSAU

Polythematic online scientific journal
of Kuban State Agrarian University
ISSN 1990-4665
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Piven Aleksandr Vladimirovich

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Children's city clinical hospital №1
   

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Articles count: 1

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NON-INVASIVE DIAGNOSTICS OF ANEUPLOIDY OF A FETUS WITH CIRCULATING TROPHOBLAST CELLS IN MATERNAL BLOOD

abstract 1231609131 issue 123 pp. 1965 – 1984 30.11.2016 ru 154
Isolation of fetal cells from the blood of a pregnant woman is more relevant for receiving the information of the genome of a fetus and implementation in clinical practice, non-invasive screening methods for prenatal diagnosis. The work proposes efficient ways of sorting trophoblasts circulating in maternal blood for the diagnosis of fetal aneuploidy in early gestation by analyzing microsatellite marker of the chromosomes that most prone to numerical aberrations (13, 18, 21, X and Y). A set of microsatellite markers allowed to reveal aneuploidy in three pregnant women, and also to exclude mosaicism and contamination of samples with maternal cells. A retrospective analysis of data on invasive cytogenetic studies (chorionic villus sampling) confirmed the results of the study
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