Scientific Journal of KubSAU

Polythematic online scientific journal
of Kuban State Agrarian University
ISSN 1990-4665
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Name

Mamsirova Svetlana Kirmizovna

Scholastic degree

• Candidate of Pharmaceutical Sciences

Academic rank

Honorary rank

Organization, job position

Krasnodar Regional Basic Medical College
   

Web site url

Email

Mamsirova_svetlana@mail.ru


Articles count: 1

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PRECLINICAL STUDIES OF PHARMACOLOGICAL PROPERTIES OF A NEW DRUG URITOSOM FOR THE TREATMENT AND PREVENTION DISEASES OF GENITOURINARY SYSTEM

abstract 1241610056 issue 124 pp. 852 – 861 30.12.2016 ru 159
In this study, the authors have defined the acute, subchronic and chronic toxicity of Uritosom preparation, and also its skin-irritating and sensitizing action. The studies that determined the acute toxicity of the drug Uritosom found that remedy which intended for the treatment and prevention of diseases of the genitourinary system with internal method of appointment during the entire observation period did not cause the death and acute toxicity in laboratory animals. In the study of subchronic and chronic toxicity of the drug Uritosom throughout the observation period in both experimental groups death and acute intoxication in animals not registered, also there were no negative phenomena in behavior, reflexes were saved. Consequently, the preparation according to the degree of impact on the body of warm-blooded animals refers to low-hazard substances (4th class of hazard according to GOST 12.1.007-76). Study of the irritant action of Uritosom preparation was carried out in two series of experiments. In the first series of experiments was determined irritating action by conjunctival swab sampling method, in the second - by skin application. The study of the sensitizing action of the drug was determined by the method of maximum sensitizing effects. The authors have found that the preparation has no irritating and sensitizing effect on the tissue in its application zone. On this basis, Uritosom preparation at different ways of application is low-toxic and it can be recommended for clinical research
.