Comparative analysis of the informativity of ultrasonic
and radiographic examination of the lungs at the initial
diagnosis of inflammatory infiltrate and at case followup
of its involution during treatment was performed in
154 children with pneumonia. Higher informativity of
ultrasound compared with radiography was
determined. All children underwent ultrasound
monitoring of pneumonia since admission to the full
restoration of normal ultrasound image. Assessment
criteria of pneumonia involution were the size and
echostructure of an airless zone. Stationary ultrasound
was performed at least 3 times. Outpatient ultrasound
was repeated at least 2 times within 1 month, in some
cases children were observed up to 3 months with
monthly dualfold study
It is proposed to use the visualization method of
propagation of excitation in the nerve in a highfrequency
electric field
The article describes the visualization of the space of initial excitation area in sinoatrial node of the cat’s heart
The aim of the research is to study the peculiarities of
vaginal microbiocenosis in female patients with
metabolic syndrome during peri- and postmenopause.
320 women in the climacteric period aged of 45-70
were examined. Two groups were formed: the main
group (160 female patients with metabolic syndrome),
the control group (160 women without metabolic
syndrome). The average age of women 54.5 ± 7.2
years. Depending on the length of menopause each of
the two groups was divided into three
subgroups.Microscopy of vaginal smears, the
colpocytological analysis, the culture test of vaginal
discharge were conducted. The statistical processing of
the results was carried out with the help of programme
sets Microsoft Office 2010 (MicrosoftExcel) and
«STATISTICA® for Windows 6.0». A tendency of
decreasing frequency of non-specific vaginitis with
aging and of increasing frequency of vaginal atrophy,
disorders of vaginal biocenosis (lactobacillus
deficiency and the domination of conditionally
pathogenic microorganisms) was discovered. The
frequency of vaginal atrophy in women with a length
of postmenopause of 10 years and older was 65.9% in
the subgroup of in female patients with metabolic
syndrome and 63.6% in the subgroup of female
patients patients without it. The more observable
changes in vaginal biotope were found in women with
metabolic syndrome
Uterine cancer is the sixth on prevalence of cancer
among women in developed countries. Hyper-estrogen
level by endogenous or exogenous origin plays the
leading role in this disease pathogenesis. This study
purpose was investigating the expression of genetic
loci responsible for the estrogen reception and
metabolism to better understanding of the molecular
mechanisms of uterine tissues malignancy. We
investigated the relative expression of genes (CYP1A
1, CYP1A 2, CYP1B 1, CYP19A, ESR1, ESR2, GPER,
STS, SULT1A and SULT1E1) by real-time PCR in
tumor and conditionally healthy uterine tissues of 27
female patients in Southern Russia aged 38-72 years
with histologically confirmed diagnosis of uterine
cancer. It is found that transcription activity of these
genes during malignancy of uterine tissues depends of
female patients age and the stage of tumor cells
differentiation. It is found that malignancy change in
the transcriptional activity of investigated genes in
uterine tissue depends of patients age and stage of
tumor cells differentiation. Particularly, it was found,
that changes of gene transcription balance of enzymes
that provide sulfation and hydrolysis of steroid sulfates is depending of patient age and the degree of tumor
cells differentiation. In addition, the sinking of gene
expression of nuclear estrogen receptor ESR1 as
lowering cell differentiation of tumor tissues. We have
also shown gene expression of nuclear estrogen
receptor ESR1 decline as lowering cell differentiation
of tumor tissues
While studying the content of hypoxia-inducible factor
1-alpha and vascular endothelial growth factor in the
tumor tissue, oral fluid and peripheral blood of 141
patients with oral mucosa cancer T1-3N0-2M0, it was
shown that the development of purulent inflammatory
postoperative complications in patients with oral
mucosa cancer is associated with an increased
expression of HIF-1α in the tissue and its translocation
from the cytoplasm to the nucleus, activation of the
neoangiogenesis processes. It is informative to
determine HIF-1α factor in the blood serum, which,
for further development, can be used as a non-invasive
diagnostic marker to predict the postoperative course
in this category of patients
Recently, much attention is paid to research the role of cell-cell interactions by gap junctions in the process of malignant transformation and mechanisms of antitumor resistance. Meanwhile, the greatest interest is astrocytic tumors. Depending on the degree of malignancy, astrocytomas are divided into: pilocytic astrocytoma (Grade I), subependymal giant cell astrocytoma (Grade I), pleomorphic xanthoastrocytoma (Grade II), diffuse astrocytoma (Grade II), anaplastic astrocytoma (Grade III), glioblastoma (Grade IV ) gliomatosis cerebri (Grade IV). Information of literature devoted to astrocytic tumors (gliomas) - the most common brain tumor in large part obtained in studies in cell cultures and different contradictions. Along with data on the reduction of glial tumors cells communicability through GJ, there is evidence of an opposite character - a functionally active GJ in gliomas and inhibition of tumor growth by reducing intercellular communicability by GJ. However, up to now there have been no studies of the effect and function of hemichannels in cancer cells, which would provide detailed information on: 1) the characteristic of presence and relative abundance of hemichannels in cancer cells; 2) evaluation of absorption / release of hemichannels mediated molecules in tumor cells than in non-tumor cells; 3) functional consequences of activation and blocking of hemichannels in tumor cells and 4) the prognostic value of the expression / activation of hemichannels in human malignancies
Regulatory-adaptive status of pregnant women with
diabetes should be considered at the solution of the
delivery
In this article we have listed the data concerning the
influence of the respiration depth on the parameters of
the cardiopulmonary synchronism depending on the
personality type
The research shows the possibility of extended
preimplantation genetic screening (PGD) that allows
to improve the strategy of selection of embryos that
satisfies not only the requirement of the absence of
chromosomal abnormalities, but also includes their
additional check for predisposition to various diseases,
as well as the choice of the embryo with the most
optimal HLA haplotype in cases with expressed
compatibility of parents for HLA-genes