The aim of the study is to compare the traditional
clinicopathologic factors and prognosis of cell cycle
parameters, such as ploidy, cell cycle kinetics, as well
as the study of DNA content in the tumor tissue of
patients with esophageal cancer. Cancer of the
esophagus - a very aggressive malignant disease, most
commonly manifested impaired swallowing. As a rule,
this type of cancer pathology is characterized by
unfavorable outcome. Ploidy and cell proliferation
activity, defined by the content of the DNA of the
tumor - synthesizing cells are one of the important
indicators of the growth rate of malignancy and
prognosis. The study was performed on tumor tissue
fragments of the 30 patients operated on for cancer of
the esophagus. DNA study - conducted in the open cell
material aftercare. DNA cell content was determined
by flow cytometry BD FACSCanto II. By studying the
DNA-cytometric parameters, we found the prevalence of aneuploid tumors in 66.7%. It was shown that DNAcytometric
parameters are independent of gender.
Major weight of diploid and aneuploid cell tumors of
the esophagus was in G0 / 1 phase of the cell cycle.
Comparative analysis of DNA - cytometric parameters
and the degree of differentiation of esophageal tumor
revealed a prevalence of aneuploid tumors in all the
test cases. content distribution pattern of tumor cells
was found in the G0 / G1-, G2 + M -, S - phase of the
cell cycle at different stages of the disease
While studying the content of hypoxia-inducible factor
1-alpha and vascular endothelial growth factor in the
tumor tissue, oral fluid and peripheral blood of 141
patients with oral mucosa cancer T1-3N0-2M0, it was
shown that the development of purulent inflammatory
postoperative complications in patients with oral
mucosa cancer is associated with an increased
expression of HIF-1α in the tissue and its translocation
from the cytoplasm to the nucleus, activation of the
neoangiogenesis processes. It is informative to
determine HIF-1α factor in the blood serum, which,
for further development, can be used as a non-invasive
diagnostic marker to predict the postoperative course
in this category of patients
It is proposed to use the visualization method of
propagation of excitation in the nerve in a highfrequency
electric field
A retrospective immunohistochemical study of lymphocyte and macrophage infiltration in tumor tissue of 84 vulvar cancer patients with a long (over 2 years) and short (less than 2 years) remission was performed to determine a possible role of immunologic microenvironment of tumors in maintaining remission. Vulvar cancer patients with a short remission period were aged 46-85 years, mean age 67 years. 15.8% of them had stage I of the disease, 21% - stage II, 47.4% - stage III and 15.8% - stage IV. The average duration of remission in this group was 11 months. Patients with a long remission period were aged 27-71 years, mean age 48 years. 38.5% of them had stage I of the disease, 53.8% - stage II and 7.7% - stage III. The average duration of remission in this group was 8 years. Histological study showed squamous cell carcinoma in all patients. Stroma and parenchyma of tumor tissues demonstrated lymphocyte and macrophage infiltration of various degrees with the predominance of T-lymphocytes. CD8+ cells prevailed in tumor tissue of patients with a long remission period (over 2 years), while a higher level of CD4+ Т-lymphocytic infiltration was associated with a short remission (less than 2 years) and a poor prognosis. These differences allow prediction of the vulvar cancer course and its early or late recurrence
The article analyzes the effectiveness of
plasmapheresis and xenon therapy in 40 patients with
gynecological cancer who underwent surgery in the
amount of extended panhysterectomy about cervical
cancer, who developed signs of post-castration
syndrome in the immediate postoperative period. The
content of gonadotropic pituitary hormones was
determined in the blood of patients with cervical
cancer and healthy women - follicule-stimulating,
luteinizing hormones, prolactin; steroid hormones:
estradiol, testosterone, cortisol; thyroid hormones. It is
found that xenon therapy has a more pronounced
antistress, hormone-modulating, sedative and
antidepressant effect and is more preferable to treat
post-castration syndrome. Performing of
plasmapheresis in this aspect is most justified in
patients with concomitant metabolic syndrome
The article describes the visualization of the space of initial excitation area in sinoatrial node of the cat’s heart
The article shows that via the dynamics of the
regulatory adaptive status it is possible to asses the
effectiveness of the treatment for the patients with
angina pectoris (third functional class)
It is known that there are most widespread the
diseases of cardiovascular system among the
examined seamen. We have carried out the analysis
of distribution of concrete nosological forms of
pathology of cardiovascular system and concomitant
diseases (gastrointestinal tract, nervous system, ENT
organs, the musculoskeletal apparatus and others).
Results of preventive screening of the crew
personnel performed in 2007–2010 by medical
commission of Novorossiysk clinical center of
Russia’s Federal Medico-Biological Agency were
subject to scientific research. 3352 seamen aged
from 18 to 60 years (middle age 27,2+1,3 years),
among which 2627 surveyed – personnel of bluewater
shipping, 725 surveyed – personnel of
domestic shipping have been subjected to studying.
The examined contingent is ranged taking into
account professional groups. It is revealed that
cardiovascular pathology is almost equally
widespread in all professional groups of personnel of
ships of domestic and blue-water shipping. This
pathology occurs at 13,5–21% of the seamen
corresponding who had medical examination. The
main group of the examined seamen (79–96,7%)
belongs to the category «almost healthy» and
suitable for work in the sea. Among revealed
pathology at seamen, the high specific weight (63–
70%) belongs to diseases of cardiovascular system. Probable intensive work and harmful factors of the
ship environment in each of professional groups
exert significant negative impact on psychic and
somatic health of seamen. Neurocirculator dystonia
(hypertensive and cardio types) dominates in
structure of cardiovascular pathology registered at
seamen of both professional groups. The associated
diseases (71–82%) meet more often at persons with
hypertension, manifesting forms of atherosclerosis
and ischemic disease. In both groups, we have noted
the high percent of violations of digestive tract,
musculoskeletal apparatus, alimentary and
constitutional obesity and eyesight. However,
alimentary and constitutional obesity and diseases of
musculoskeletal apparatus are most characteristic of
the personnel of ships performing long maritime
traffic. Obviously, this phenomenon is connected
with hypodynamia
The article presents an analysis of features of the
organization of special medical and prophylactic
support on commercial ships. First-aid treatment at
poisoning of crews of the most widespread toxic
matter (poisonous gases, oil products, methane,
coolants, and fumigants) has been considered. It is
noted that medical aspects of toxic dangers on the
water transport have to include prevention of the
pathological states of health of seamen, timely medical
support of the ship, early diagnostics of pathological
states, sorting of injured persons and the organization
of first emergency medical aid
The aim of the research is to study the peculiarities of
vaginal microbiocenosis in female patients with
metabolic syndrome during peri- and postmenopause.
320 women in the climacteric period aged of 45-70
were examined. Two groups were formed: the main
group (160 female patients with metabolic syndrome),
the control group (160 women without metabolic
syndrome). The average age of women 54.5 ± 7.2
years. Depending on the length of menopause each of
the two groups was divided into three
subgroups.Microscopy of vaginal smears, the
colpocytological analysis, the culture test of vaginal
discharge were conducted. The statistical processing of
the results was carried out with the help of programme
sets Microsoft Office 2010 (MicrosoftExcel) and
«STATISTICA® for Windows 6.0». A tendency of
decreasing frequency of non-specific vaginitis with
aging and of increasing frequency of vaginal atrophy,
disorders of vaginal biocenosis (lactobacillus
deficiency and the domination of conditionally
pathogenic microorganisms) was discovered. The
frequency of vaginal atrophy in women with a length
of postmenopause of 10 years and older was 65.9% in
the subgroup of in female patients with metabolic
syndrome and 63.6% in the subgroup of female
patients patients without it. The more observable
changes in vaginal biotope were found in women with
metabolic syndrome