Uterine cancer is the sixth on prevalence of cancer
among women in developed countries. Hyper-estrogen
level by endogenous or exogenous origin plays the
leading role in this disease pathogenesis. This study
purpose was investigating the expression of genetic
loci responsible for the estrogen reception and
metabolism to better understanding of the molecular
mechanisms of uterine tissues malignancy. We
investigated the relative expression of genes (CYP1A
1, CYP1A 2, CYP1B 1, CYP19A, ESR1, ESR2, GPER,
STS, SULT1A and SULT1E1) by real-time PCR in
tumor and conditionally healthy uterine tissues of 27
female patients in Southern Russia aged 38-72 years
with histologically confirmed diagnosis of uterine
cancer. It is found that transcription activity of these
genes during malignancy of uterine tissues depends of
female patients age and the stage of tumor cells
differentiation. It is found that malignancy change in
the transcriptional activity of investigated genes in
uterine tissue depends of patients age and stage of
tumor cells differentiation. Particularly, it was found,
that changes of gene transcription balance of enzymes
that provide sulfation and hydrolysis of steroid sulfates is depending of patient age and the degree of tumor
cells differentiation. In addition, the sinking of gene
expression of nuclear estrogen receptor ESR1 as
lowering cell differentiation of tumor tissues. We have
also shown gene expression of nuclear estrogen
receptor ESR1 decline as lowering cell differentiation
of tumor tissues
The article presents the evaluation of the lability of the visual analyzer among healthy individuals and patients with lesion after a stroke in the occipital cortex, temporal and parietal lobes
The aim of this work: a study of health - social and ethical aspects of health care workers in the framework of the prevention of a healthy lifestyle among youth. To study the level of students' knowledge about HIV prevention and detection of bad habits - drinking, smoking, drug addiction, a study author profiles. We
have used empirical, sociological and statistical methods
Isolation of fetal cells from the blood of a pregnant
woman is more relevant for receiving the information
of the genome of a fetus and implementation in clinical
practice, non-invasive screening methods for prenatal
diagnosis. The work proposes efficient ways of sorting
trophoblasts circulating in maternal blood for the
diagnosis of fetal aneuploidy in early gestation by
analyzing microsatellite marker of the chromosomes
that most prone to numerical aberrations (13, 18, 21, X
and Y). A set of microsatellite markers allowed to
reveal aneuploidy in three pregnant women, and also
to exclude mosaicism and contamination of samples
with maternal cells. A retrospective analysis of data on
invasive cytogenetic studies (chorionic villus
sampling) confirmed the results of the study
The dramatic lowering of intraocular pressure
(hypotony) is developing during glaucomatous surgery
due to the formation of the new aqueous humor
outflow. The calculations of the flow in the fluid
balance parameters have shown, that for the normal
intraocular pressure maintenance in the postoperative
period the fluid flow out of the anterior chamber
should not exceed 0,04 microliter in minute. The
intensity of the aqueous humor outflow through the
shunts with different parameters does not depend on
the shunt length. The shunt with the inner hole radius
0,025 mm is the most safe as it provide the less
outflow. The experimental comparative study of the
static viscosity of the most widely used viscoelastics in
ophthalmological surgery was carried out. It was stated
that used in eye surgery viscoelastics on the basis of
1%, 2% and 3% sodium hyaluronate possess the
viscosity, that differs in 10 and 100 times and has
significant influence on the flow intensity out of the
anterior chamber when the new outflow tracts are
formed. The mathematically based choice of the most
optimal relationship between the viscoelastics physical
parameters and the inner hole size of the shunt type
glaucoma drainage devices was established. Shunt
with the inner hole radius 0,05 mm and simultaneous
use of 2% and 3% sodium hyaluronate solution is the
most safe for the maintenance of the eye tonus during
the first 5 days after glaucoma surgery. The presented
correlation allows to increase the safety of the surgical
treatment of the patients with the refractory glaucoma
Pathology of digestive organs is high on the list in
structure of diseases of children and teenagers. Now
many pediatricians face that teenagers at the same
time have several diseases. The most exact method of
detection of the available pathology is medical
examination. These inspections of rural teenagers with
chronic gastroenterological pathology are given in
article. The carried-out work allowed revealing the
main features of a state of health of this contingent
The results of the questionnaire survey of cadets of
Maritime University, Maritime College and students
who had been given training in the Institution of
Advanced Training are presented. It is revealed that
the level of motivation of ship personnel for first aid
treatment to victims on commercial ships is two times
lower than that of cadets. The conclusion about the
necessity of solution the legal aspects of sailorsparamedics,
working under the Russian flag was made
The research shows the possibility of extended
preimplantation genetic screening (PGD) that allows
to improve the strategy of selection of embryos that
satisfies not only the requirement of the absence of
chromosomal abnormalities, but also includes their
additional check for predisposition to various diseases,
as well as the choice of the embryo with the most
optimal HLA haplotype in cases with expressed
compatibility of parents for HLA-genes
Regulatory-adaptive status of pregnant women with
diabetes should be considered at the solution of the
delivery
The problem of rendering of first medical aid to
personnel of commercial ships under the Russian flag
is considered. It is shown that the decision of this
problem in our country is impossible without juridical
aspects of activity of sailors-paramedics, questions of
their training in bases of rendering an emergency aid
and due medical support of the Russian ships. The
emergency elementary aid has to be an integral part of
activity of personnel of ships. Some directions of the
decision of a problem of efficiency of providing such
help to personnel of ships are proposed. Development
of the bill directed to introduction in Russia of
requirements for assistance by paramedics on
commercial ships is necessary