The index definition of regulatory-adaptive status in
women with the threat of termination of pregnancy in
the first trimester is a highly predictor of pregnancy
outcome and should be used in obstetric hospitals and
antenatal clinics
The aim of the research is to assess the effect of
different kinds of non-drug correction of climacteric
disorders on the sexual function in female patients
with metabolic syndrome during the period of fading
of the ovaries. The research includes 330 women aged
45-50 and having metabolic symptoms. Three groups
were formed: the main group, the first control group,
and the second control group. In the main group the
non-drug treatment (diet therapy, psychotherapy,
physical therapy, exercise therapy) and the vitaminmineral
treatment were combined. In the first control
group, only non-drug treatment was used. In the
second control group, only the vitamin-mineral
treatment was used. The marital status was determined.
The female sexual function index (FSFI) was
determined based on six parameters – desire, arousal,
lubrication, orgasm, satisfaction, and pain – before the
treatment and six months after the treatment. It was
identified that sexual disorders are of complex
character in the women of the studied group; very
common is the loss of libido. The results show the
highest effectiveness of the complex approach (nondrug
treatment combined with the vitamin-mineral
treatment) in the sexual dysfunction correction in
female patients with metabolic syndrome in the
climacteric period compared to the use of only the
stated methods of non-drug treatment or only the
vitamin-mineral treatment
Trophoblast cells circulating in maternal blood may
serve as potential sources of genetic information for
screening in obstetric practice approaches to
noninvasive prenatal diagnosis. The material for the
study was whole blood of pregnant women of
gestational ages of 8-12 weeks in a volume of 10 ml.
stabilized with heparin. Enrichment was performed by
the method of gradient centrifugation and magnetic
separation (CD45–) with fluorescent staining negative
fractions labeled with antibodies to antigens of
trophoblasts (HLA-G, and Trop-2) to conduct flow
cytometry and sorting of cells on glass slides. Single
cell candidates using laser micro dissection were
transferred into a vial for subsequent whole-genome
amplification, providing sufficient representativeness
of their genome. Fetal origin of the genetic material
was confirmed by comparison of alleles of the HLA
genes of the parents and cells candidates. It is possible
to improve significantly the accuracy and versatility of
non-invasive prenatal diagnosis using comparative
genomic hybridization using chips (аCGH)
The aim of the research was to assess the effect of nondrug
correction of urogenital disorders in female
patients with metabolic syndrome during the
menopause. The research includes 330 women aged
45-50 with metabolic syndrome. Three equal groups
with 110 female patients each were formed: the main
group, the first control group, and the second control
group. In the main group, the non-drug treatment (diet
therapy, psychotherapy, physical therapy, exercise
therapy) and the vitamin-mineral treatment were
combined. In the first control group, only non-drug
treatment was used. In the second control group, only
the vitamin-mineral treatment was used. Before the
treatment and in six months after the treatment, the
following was assessed: the intensity of vaginal
atrophy symptoms according to the 5-point Barlow
scale; Bochman vaginal health index; urinary diaries
data. The results of the research showed: the average
value of Bochmanvaginal health index has most
significantly increased in the main group (from
3,64±0,63 pointsto 4,67±0,68 points, p
The aim of the research was to assess the effect of nondrug
correction methods of climacteric disorders on
the digestive system in patients with metabolic syndrome.
330 women aged 45-50 with the diagnosed
metabolic syndrome were examined. Three comparable
groups were formed with 110 female patients in
each group. In the main group the methods of the nondrug
treatment (diet therapy, psychotherapy, physical
therapy, exercise therapy) and the vitamin-mineral
treatment were combined. In the first control group
only the non-drug treatment was used. In the second
control group only the vitamin-mineral treatment was
used. The female patients’ complaints and the biochemical
profile parameters were assessed before the
treatment and six months after the treatment. Ultrasound
scanning of the abdominal cavity, fibrogastroduodenoscopy
and videocolonoscopy were carried out.
The results of the study are as follows. In all patients
the digestive tract problems were diagnosed at the beginning
of the research. Moreover, combined damages
were noticedin most of the patients. The main group
demonstrated the most pronounced positive dynamic
according to the subjective evaluation of the symptoms
as to the gastrointestinal tract, as well as according to
the parameters of the carbohydrate and fat metabolism.
We may conclude that the complex non-drug correction
of climacteric disorders in female patients with
metabolic syndrome, directed on the increase of the
adaptation abilities of thewomen’s organism, the normalization
of all kinds of metabolism and of the endocrine
profile, has the most important positive effect on
the organs of the gastrointestinal tract. This, in its turn,
well coordinates all the kinds of metabolism
The article analyzes the effectiveness of
plasmapheresis and xenon therapy in 40 patients with
gynecological cancer who underwent surgery in the
amount of extended panhysterectomy about cervical
cancer, who developed signs of post-castration
syndrome in the immediate postoperative period. The
content of gonadotropic pituitary hormones was
determined in the blood of patients with cervical
cancer and healthy women - follicule-stimulating,
luteinizing hormones, prolactin; steroid hormones:
estradiol, testosterone, cortisol; thyroid hormones. It is
found that xenon therapy has a more pronounced
antistress, hormone-modulating, sedative and
antidepressant effect and is more preferable to treat
post-castration syndrome. Performing of
plasmapheresis in this aspect is most justified in
patients with concomitant metabolic syndrome
The aim of the research is to study the peculiarities of
vaginal microbiocenosis in female patients with
metabolic syndrome during peri- and postmenopause.
320 women in the climacteric period aged of 45-70
were examined. Two groups were formed: the main
group (160 female patients with metabolic syndrome),
the control group (160 women without metabolic
syndrome). The average age of women 54.5 ± 7.2
years. Depending on the length of menopause each of
the two groups was divided into three
subgroups.Microscopy of vaginal smears, the
colpocytological analysis, the culture test of vaginal
discharge were conducted. The statistical processing of
the results was carried out with the help of programme
sets Microsoft Office 2010 (MicrosoftExcel) and
«STATISTICA® for Windows 6.0». A tendency of
decreasing frequency of non-specific vaginitis with
aging and of increasing frequency of vaginal atrophy,
disorders of vaginal biocenosis (lactobacillus
deficiency and the domination of conditionally
pathogenic microorganisms) was discovered. The
frequency of vaginal atrophy in women with a length
of postmenopause of 10 years and older was 65.9% in
the subgroup of in female patients with metabolic
syndrome and 63.6% in the subgroup of female
patients patients without it. The more observable
changes in vaginal biotope were found in women with
metabolic syndrome
Prostate cancer (PC) is one of the most frequently
malignant neoplasms in the worldwide male
population. Back in the 90's began a promising noninvasive
method of high-intensity focused ultrasound
(HIFU) as an alternative to radical prostatectomy for
the treatment of localized prostate cancer was used.
Information about the destructive histological effect by
HIFU has been known since the 1930, however, the
clinical implementation of this technology due to the
absence at the time visualization capabilities for
monitoring during the procedure has been postponed.
In this paper, an overview of published data on the
HIFU clinical application in prostate cancer as a major,
"saving" and focal therapy. Examples of a favorable
combination of this method are also provided with
pharmacological agents. Based on the analysis of
clinical data, we can say that HIFU is a good
alternative minimally invasive therapeutic modality for
patients with prostate cancer who are not candidates
for radical prostatectomy. Applying of HIFU is
possible as a treatment option with local recurrence
after external radiotherapy, with careful selection of
patients is important, depending on prognostic factors
Mortality from malignant diseases is directly linked to
early metastasis and relapse. It is now possible to
identify individual tumor cells in bone marrow
biopsies and peripheral blood. Colorectal cancer is one
of the leading places in the structure of cancer
incidence and mortality, both in Russia and around the
world. Studies have shown that after surgery the ability
of tumor cells to the dissemination and implantation
increases. The work contains 30 patients with the
verified colorectal cancer with metastasis to the liver.
To determine the CSC we have applied an analysis
technology in CellSearch System â„¢ (Janssen
Diagnostics, LLC). Our study of the number and
frequency of detection of circulating tumor cells in
peripheral blood of patients and control group
demonstrates the reduction in the number of CTCs
during laparoscopic surgery and changing the
dynamics of the level of tumor cells in the form of
reduction from the stage of the mobilization of the drug due to minimally invasive access, minimizing
manipulation in the projection of the tumor and as a
consequence, preventing the release into the blood
stream of single tumor cells
Isolation of fetal cells from the blood of a pregnant
woman is more relevant for receiving the information
of the genome of a fetus and implementation in clinical
practice, non-invasive screening methods for prenatal
diagnosis. The work proposes efficient ways of sorting
trophoblasts circulating in maternal blood for the
diagnosis of fetal aneuploidy in early gestation by
analyzing microsatellite marker of the chromosomes
that most prone to numerical aberrations (13, 18, 21, X
and Y). A set of microsatellite markers allowed to
reveal aneuploidy in three pregnant women, and also
to exclude mosaicism and contamination of samples
with maternal cells. A retrospective analysis of data on
invasive cytogenetic studies (chorionic villus
sampling) confirmed the results of the study