The index definition of regulatory-adaptive status in
women with the threat of termination of pregnancy in
the first trimester is a highly predictor of pregnancy
outcome and should be used in obstetric hospitals and
antenatal clinics
Mortality from malignant diseases is directly linked to
early metastasis and relapse. It is now possible to
identify individual tumor cells in bone marrow
biopsies and peripheral blood. Colorectal cancer is one
of the leading places in the structure of cancer
incidence and mortality, both in Russia and around the
world. Studies have shown that after surgery the ability
of tumor cells to the dissemination and implantation
increases. The work contains 30 patients with the
verified colorectal cancer with metastasis to the liver.
To determine the CSC we have applied an analysis
technology in CellSearch System â„¢ (Janssen
Diagnostics, LLC). Our study of the number and
frequency of detection of circulating tumor cells in
peripheral blood of patients and control group
demonstrates the reduction in the number of CTCs
during laparoscopic surgery and changing the
dynamics of the level of tumor cells in the form of
reduction from the stage of the mobilization of the drug due to minimally invasive access, minimizing
manipulation in the projection of the tumor and as a
consequence, preventing the release into the blood
stream of single tumor cells
The article shows that via the dynamics of the
regulatory adaptive status it is possible to asses the
effectiveness of the treatment for the patients with
angina pectoris (third functional class)
The aim of the research was to assess the effect of nondrug
correction methods of climacteric disorders on
the digestive system in patients with metabolic syndrome.
330 women aged 45-50 with the diagnosed
metabolic syndrome were examined. Three comparable
groups were formed with 110 female patients in
each group. In the main group the methods of the nondrug
treatment (diet therapy, psychotherapy, physical
therapy, exercise therapy) and the vitamin-mineral
treatment were combined. In the first control group
only the non-drug treatment was used. In the second
control group only the vitamin-mineral treatment was
used. The female patients’ complaints and the biochemical
profile parameters were assessed before the
treatment and six months after the treatment. Ultrasound
scanning of the abdominal cavity, fibrogastroduodenoscopy
and videocolonoscopy were carried out.
The results of the study are as follows. In all patients
the digestive tract problems were diagnosed at the beginning
of the research. Moreover, combined damages
were noticedin most of the patients. The main group
demonstrated the most pronounced positive dynamic
according to the subjective evaluation of the symptoms
as to the gastrointestinal tract, as well as according to
the parameters of the carbohydrate and fat metabolism.
We may conclude that the complex non-drug correction
of climacteric disorders in female patients with
metabolic syndrome, directed on the increase of the
adaptation abilities of thewomen’s organism, the normalization
of all kinds of metabolism and of the endocrine
profile, has the most important positive effect on
the organs of the gastrointestinal tract. This, in its turn,
well coordinates all the kinds of metabolism
The aim of the research is to assess the effect of
different kinds of non-drug correction of climacteric
disorders on the sexual function in female patients
with metabolic syndrome during the period of fading
of the ovaries. The research includes 330 women aged
45-50 and having metabolic symptoms. Three groups
were formed: the main group, the first control group,
and the second control group. In the main group the
non-drug treatment (diet therapy, psychotherapy,
physical therapy, exercise therapy) and the vitaminmineral
treatment were combined. In the first control
group, only non-drug treatment was used. In the
second control group, only the vitamin-mineral
treatment was used. The marital status was determined.
The female sexual function index (FSFI) was
determined based on six parameters – desire, arousal,
lubrication, orgasm, satisfaction, and pain – before the
treatment and six months after the treatment. It was
identified that sexual disorders are of complex
character in the women of the studied group; very
common is the loss of libido. The results show the
highest effectiveness of the complex approach (nondrug
treatment combined with the vitamin-mineral
treatment) in the sexual dysfunction correction in
female patients with metabolic syndrome in the
climacteric period compared to the use of only the
stated methods of non-drug treatment or only the
vitamin-mineral treatment
The dramatic lowering of intraocular pressure
(hypotony) is developing during glaucomatous surgery
due to the formation of the new aqueous humor
outflow. The calculations of the flow in the fluid
balance parameters have shown, that for the normal
intraocular pressure maintenance in the postoperative
period the fluid flow out of the anterior chamber
should not exceed 0,04 microliter in minute. The
intensity of the aqueous humor outflow through the
shunts with different parameters does not depend on
the shunt length. The shunt with the inner hole radius
0,025 mm is the most safe as it provide the less
outflow. The experimental comparative study of the
static viscosity of the most widely used viscoelastics in
ophthalmological surgery was carried out. It was stated
that used in eye surgery viscoelastics on the basis of
1%, 2% and 3% sodium hyaluronate possess the
viscosity, that differs in 10 and 100 times and has
significant influence on the flow intensity out of the
anterior chamber when the new outflow tracts are
formed. The mathematically based choice of the most
optimal relationship between the viscoelastics physical
parameters and the inner hole size of the shunt type
glaucoma drainage devices was established. Shunt
with the inner hole radius 0,05 mm and simultaneous
use of 2% and 3% sodium hyaluronate solution is the
most safe for the maintenance of the eye tonus during
the first 5 days after glaucoma surgery. The presented
correlation allows to increase the safety of the surgical
treatment of the patients with the refractory glaucoma
The dramatic lowering of intraocular pressure (hypotony) is developing during glaucomatous surgery due to the formation of the new aqueous humor outflow. The calculations of the flow in the fluid balance parameters have shown, that for the normal intraocular pressure maintenance in the postoperative period the fluid flow out of the anterior chamber should not exceed 0,04 microliter in minute. The intensity of the aqueous humor outflow through the shunts with different parameters does not depend on the shunt length. The shunt with the inner hole radius 0,025 mm is the most safe as it provide the less outflow. The experimental comparative study of the static viscosity of the most widely used viscoelastics in ophthalmological surgery was carried out. It was stated that used in eye surgery viscoelastics on the basis of 1%, 2% and 3% sodium hyaluronate possess the viscosity, that differs in 10 and 100 times and has significant influence on the flow intensity out of the anterior chamber when the new outflow tracts are formed. The mathematically based choice of the most optimal relationship between the viscoelastics physical parameters and the inner hole size of the shunt type glaucoma drainage devices was established. Shunt with the inner hole radius 0,05 mm and simultaneous use of 2% and 3% sodium hyaluronate solution is the most safe for the maintenance of the eye tonus during the first 5 days after glaucoma surgery. The presented correlation allows to increase the safety of the surgical treatment of the patients with the refractory glaucoma
Acceptable values of the drainage hole parameters in the shunt glaucoma surgery were calculated by means of mathematical modeling of different conditions of eye hydrodynamics. The operation method was designed with provision for pressure gradient, rate of the aqueous humor outflow, and the values of intraocular pressure in early and late postoperative period. The balance of liquid in eye was calculated in mathematical model as ordinary differential equation in accordance with flow resistance of every section. The data received by using mathematical model has shown that allowable rate of aqueous humor outflow is gained with the hole diameter of 0,025 mm. This mathematical model should assist to the better understanding of physical processes describing the eye hydrodynamics, should benefit to the operation quality and should create the base to the clinical studies
The aim of the research was to assess the effect of nondrug
correction of urogenital disorders in female
patients with metabolic syndrome during the
menopause. The research includes 330 women aged
45-50 with metabolic syndrome. Three equal groups
with 110 female patients each were formed: the main
group, the first control group, and the second control
group. In the main group, the non-drug treatment (diet
therapy, psychotherapy, physical therapy, exercise
therapy) and the vitamin-mineral treatment were
combined. In the first control group, only non-drug
treatment was used. In the second control group, only
the vitamin-mineral treatment was used. Before the
treatment and in six months after the treatment, the
following was assessed: the intensity of vaginal
atrophy symptoms according to the 5-point Barlow
scale; Bochman vaginal health index; urinary diaries
data. The results of the research showed: the average
value of Bochmanvaginal health index has most
significantly increased in the main group (from
3,64±0,63 pointsto 4,67±0,68 points, p
The research shows the possibility of extended
preimplantation genetic screening (PGD) that allows
to improve the strategy of selection of embryos that
satisfies not only the requirement of the absence of
chromosomal abnormalities, but also includes their
additional check for predisposition to various diseases,
as well as the choice of the embryo with the most
optimal HLA haplotype in cases with expressed
compatibility of parents for HLA-genes