Scientific Journal of KubSAU

Polythematic online scientific journal
of Kuban State Agrarian University
ISSN 1990-4665
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335 kb

CLINICAL MANIFESTATIONS AND DISEASE PATHOLOGICAL CHANGES IN PIGS INFECTED WITH ASF VIRUS ISOLATES FROM WILD BOARS

abstract 1341710086 issue 134 pp. 1055 – 1065 29.12.2017 ru 119
This report represents the results of study of ASF clinical signs and pathological changes in dead pigs infected with an ASF virus isolated from wild boars in 2016. The ASF virus circulating among wild boars in the Central and the North-Western Districts was found to be virulent, and causes the death of animals in terms characteristic of acute and subacute forms with no development of a full symptom complex of the disease
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MORPHO-FUNCTIONAL STATE OF BROILER CHICKENS ADRENAL CAPSULES UNDER DIFFERENT METHODS OF MANAGEMENT

abstract 1341710090 issue 134 pp. 1106 – 1116 29.12.2017 ru 77
An impact analysis of abiotic factors of ecosystems on the metabolic processes of the broiler chicken organism under various methods of poultry operation has been carried out. The analysis results confirm that the enorganic biochemical processes are under the influence of the environment, and any changes in its condition cause the development of response reactions of the organism at the biochemical level. The source of control of the relative constancy of the milieu interieur is the interaction of tropic and effector hormones. Adrenocorticotropic hormone and cortisol are the main hormones of adaptation. The activity of the adrenal capsules turns to be an effector peripheral link of the reflex chain of the adaptive reaction of the organism. Adrenal hormones have a direct impact on tissue metabolism. The following aspects have been taken into consideration: technological growing conditions, production parameters, morphological blood values of chickens of different ages, quantitative content of adrenocorticotropic hormone and corticoid in the blood, morphology of the adrenal capsules. The abiotic factors of the cage management system contribute to an increase in the concentration of corticoid in the blood of broiler chickens, compared with this value of the broilers grown under the floor management
158 kb

THEORETICAL AND EXPERIMENTAL BASIS FOR THE USE OF INJECTION HEPATOPROTECTORS IN THE PROPHYLACTICS OF LIVER DISEASES IN COWS

abstract 1321708027 issue 132 pp. 335 – 345 31.10.2017 ru 290
The use of intensive milk production technologies in practice, nonobservance of the principles of feeding and keeping animals leads to a decrease in the level of compensatory-regenerative processes in the body, violation of general and specific metabolic reactions, emergence of a number of pathological conditions, and, primarily, hepatopathies leading to a decrease in the productivity of dairy cattle, to the birth of unviable young animals and to the impossibility of their further exploitation. Therefore, on the background of early diagnosis of violations of the liver it is necessary to conduct adequate pharmacoprophylaxis, which prevents further development of hepatopathies with the help of hepatoprotectors. These preparations include a new injectable one – livazen, the mechanism of action of which works due to its antioxidant and membrane-stabilizing action. The preparation has a lipotropic effect, favorably affects the antitoxic and pigmentary function of liver, and increases resistance to hypoxia and various kinds of intoxication. Research conducted to study its effect in the system of prophylactic measures of hepatosis in sterile cows showed that on the background of the use of lavazen there was a significant increase in total protein by 16,6% and increase in albumins - by 13,8%. The level of γ-globulins, on the contrary, decreased by 20,9%. The study of the preparation had a normalizing effect on lipid metabolism, which was manifested by an increase in the concentration of triglycerides in 3,1 times and increase in cholesterol by 24,7%. An increase in the concentration of calcium by 14,5% was also found out. The use of livazen allowed to ensure a tendency towards a decrease in enzyme activity (according to AST - by 6,9%, by ALT - by 24,4%, according to alkaline phosphatase - by 11,6%), in contrast to control animals whose aspartate aminotransferase increased by 11,3% from the initial; ultrasonography of liver of cows confirmed the expressed effectiveness of the pharmacoprophylaxis
171 kb

THE COMPARATIVE STUDY OF COMPOSITION OF MICROORGANISMS, WHICH WERE ISOLATED FROM NEWBORN CALVES AND PIGLETS AT ACUTE INTESTINAL DISEASES

abstract 1321708058 issue 132 pp. 728 – 741 31.10.2017 ru 213
One of the reasons extensions acute intestinal diseases in newborn calves and piglets is absence at them of formed immune system and colonization resistance. For this reason, their intestine often occupies relative pathogenic microorganisms, which in the subsequent cause diarrheal diseases. The characteristic feature of the last time is the fact that these diseases have the associated disposition and composition of association can be the most various but not only biological objects (for calves and piglets), and also territorial borders. The goal of this work was in comparative study of the structure microorganisms, which were isolated from newborn calves and piglets at acute intestinal diseases in Krasnodar territory and the establishment of the dominant species. During the bacteriologic examination of pathological material was detach and finger 1299 isolate calves and 476 from piglets which was found to belonged to 6 families: Enterobacteriaceae, Streptococcaceae, Enterococcaceae, Pseudomonadaceae, Alcaligenaceae, Alteromonadaceae. Studies have shown that dominant logic value in nosological profile of the allocated bacteria belongs to enterobacterium, enterococcus, streptococcus, the share of which in the general pool of isolates has made 70,1%, 15,9% and 11,1%, respectively. At the same time among the enterobacterium detached as from calves, and pigs, the prevailing species was E. coli (55,6%), streptococcus – S. bovis (24,9%), enterococcus – E. faecium and E. faecalis (88,3%). Meanwhile, along with the general character of frequency separation of certain types of bacteria, also their specific preference is set. That why from calves there were more often selected enterobacter, citrobacter, kluyvera, E. faecalis, S. cricetus, S. mitior, S. parauberis and P. aeruginosa. Whereas from pigs more often were allocated protei, providencia, shigella, E. mundtii, E. casseliflavus, S. acidominimus, S. oralis, S. pneumoniae, S. vestibularis и Alcaligenes fecalis than from pigs
164 kb

SECONDARY IMMUNODEFICIENCIES OF SMALL PETS AND THEIR CORRECTION USING MURAMYLDIPEPTIDE

abstract 1311707049 issue 131 pp. 559 – 571 29.09.2017 ru 301
The revolutionary discoveries of recent years in immunology has proved that protection from infections and biological aggression leading role played by innate immunity, which leads to the launch and subsequent work of specific adaptive immunity. Today, it is well-known that almost any pathology of the animal affects the immune system and creates an immune imbalance, leading to development of chronic pathological process, frequent relapses and to the development of different kind of complications. Secondary immunodeficiency states are widely distributed and differ in many etiological factors age, nutritional, medicinal, infectious and neoplastic nature, which leads to increased susceptibility of animal to various раthogenic factors, the weakening of the body. Awareness of the role of immunological disorders in the pathogenesis of a number of diseases has led to the need use in veterinary medicines that are aimed to influence on the immune system of the animal at the known molecular mechanism, to combine safety with high clinical efficacy. In this respect, a promising immunomodulators of microbial origin, due to the knowledge of the recognition mechanisms of the innate immune system such as bacteria as a whole, separate structural units, including mini-optimal biologically active fragments. This review is dedicated to one of the immunomodulator of microbial origin – which is an analog of biologically active fragment of muramyldipeptide of bacterial cell walls ‒ glucosaminylmuramildipeptide (GMDP), which is the active substance of registrated in Russia drug with the trade name Glicopin for use in veterinary practice. The drug showed high efficiency when used in cats, dogs, rodents, ferrets with infections of bacterial and viral etiology; cancer; with the aim of improving the natural resistance of the organism of young and old animals; enhance the effectiveness of vaccination in immunocompromised animals; postvaccine reduce complications; reduce stress financial position, such as during transportation and various veterinary treatments; injuries and on-line intervention (for stimulation of repair processes and tissue regeneration); prevention of immunodeficiency in newborn animals; the reduction of postpartum involutional processes in the uterus. Analysis of literature data allows us to consider an important outcome of immunologiс discoveries of recent years is the change of views on the question of the treatment of infectious diseases and the role of drugs as activators of innate immunity, among which an important role is played by a synthetic analogue of muramyldipeptide (GMDP) is a drug with a known molecular mechanism of action
161 kb

BIOLOGICAL FUNCTIONS OF CAROTENOIDS AT CATTLE REPRODUCTION

abstract 1291705080 issue 129 pp. 1113 – 1125 31.05.2017 ru 278
Carotenoid preparations are quite widely used in a health care, but in the veterinary and animal husbandry, their use is limited. In terms of livestock farms of the Krasnodar region and the Rostov region at the biochemical monitoring studies of the cattle blood the lack of carotene in the serum is revealed from 45 to 100 % of the samples. To study the biological function of carotenoid we used preparations, which are the oily solutions for injections: β-carotene (manufactured by FS 42-3867, which is produced from the biomass culture of the fungus Blakeslea trispora) and lycopene, emitted from plants. The cows in the test groups during the dry period and within two weeks after birth got carotenoid preparation subcutaneously at a dose of 10 ml per animal with an interval of 7 days. As a result, it was found out that the application of carotenoids has the most favorable conditions for the flow of labor and the postnatal period, which are manifested in the decrease in obstetric and gynecological diseases in cows and reduce the period of infertility. In the experimental groups the levels of vitamin A and carotene1,3 times higher (1,26 ± 0,14 μmol/L vs. 0,97 ± 0,09 μmol/L ) 1,8 times (0,34 ± 0 03 mg /% vs. 0.61 ± 0.11 mg /%) respectively in comparison with the parameters of the intact animals at a high level of confidence (P < 0,05). Phagocytic number and percentage of digestion of neutrophils increased by 8,5 %, the difference in the number of B-cells reached 9,1%, T-cells – 6,7%. In a humoral immunity found a significant increase in Ig A. After comparison of the level of lysozyme activity of blood serum was observed its reduction in all animals immediately after birth, but in the experimental groups this process was less pronounced. The use of carotene preparations helps to reduce the concentration of lipid peroxidation products in the body of cows (diene conjugates - by 16,6 %, ketodienes - by 35,7 %, malondialdehyde – by 11,3 %), which creates favorable conditions for the flow of the metabolic processes associated with ensuring the normal childbirth and post-partum involution of the genitals. In the group of cows, receiving the carotenoid lycopene, the dyspepsia morbidity of the newborn calves compared to a control decreased by 26,7 %, bronchopneumonia - by 13,3 %
141 kb

THE INFLUENCE OF ASSOCIATIONS OF PROBIOTIC BACTERIA ON HEMATOLOGICAL AND BIOCHEMICAL INDICATORS OF BLOOD PARAMETERS AT CALVES

abstract 1261702016 issue 126 pp. 224 – 233 28.02.2017 ru 544
The article presents results of the study on the use of associations of probiotic bacteria in black-and-white breed calves. We have analyzed the effect of associations of probiotic bacteria on hematological (red blood cells and white blood cells, hemoglobin and hematocrit) and blood biochemical parameters at calves. It was found that the associations of strains of Bifidobacterium bifidum DSM 20456, ATCC 29521, and Enterococcus faecalis H22; Bifidobacterium bifidum DSM 20456, ATCC 29521 and Enterococcus faecium UDC 86 do not have significant changes in the basic blood parameters of the animals, while improving some of counts during their use
126 kb

SEROLOGIC CONTROL OF SPECIFIC PROPHYLAXIS OF THE CANICOLA FEVER OF CATTLE

abstract 1261702035 issue 126 pp. 494 – 503 28.02.2017 ru 332
Results of studying of the immune response of young growth of cattle to vaccination against a canicola fever are presented in article. Dependence of duration of circulation of antibodies in a blood of the vaccinated young growth of cattle from degree of intensity of an immune response on introduction of the vaccine is revealed. Studying of dynamics of antiserum capacities at cow calves of two-month age after immunization taped the weak immune response on introduction of a vaccine. It is expressed both in total absence of antibodies, or available antibodies in minute quantity to canicola fever of one of the serogroups which are a part of a vaccine. Use of immunomodulatory preparations for rising of efficiency of immunization of cow calves against a canicola fever is offered. It is established that application of "Ribotan" at vaccination of two-month calves against a canicola fever increases efficiency of immunization for 55,6 %
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MONITORING OF THE CANICOLA FEVER IN POPULATION OF CATTLE AND WILD FAUNA OF THE AMUR REGION

abstract 1251701031 issue 125 pp. 464 – 473 31.01.2017 ru 482
The article presents results of researches of authors on prevalence of a canicola fever in populations of cattle and wild rodents in the Amur region. The research objective consisted in studying of etiological structure of a canicola fever of cattle and establishment of the dominating canicola fever originator serotypes at the rodents living in the Amur region. Results of researches showed that in etiological structure of a canicola fever of cattle in the Amur region the admixed serogroups and a serogroup of Sejroe dominate. The natural reservoir of a canicola fever in the Amur region are populations of gophers, chipmunks, muskrats and voles. The highest percent of the infected individuals is taped in population of gophers (57,1 %). Level of contamination of animals in populations of muskrats and chipmunks made 20 and 17,6 % respectively. Contamination the canicola fever originator in populations of voles was at the level of 8-9 %
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PRECLINICAL STUDIES OF PHARMACOLOGICAL PROPERTIES OF A NEW DRUG URITOSOM FOR THE TREATMENT AND PREVENTION DISEASES OF GENITOURINARY SYSTEM

abstract 1241610056 issue 124 pp. 852 – 861 30.12.2016 ru 352
In this study, the authors have defined the acute, subchronic and chronic toxicity of Uritosom preparation, and also its skin-irritating and sensitizing action. The studies that determined the acute toxicity of the drug Uritosom found that remedy which intended for the treatment and prevention of diseases of the genitourinary system with internal method of appointment during the entire observation period did not cause the death and acute toxicity in laboratory animals. In the study of subchronic and chronic toxicity of the drug Uritosom throughout the observation period in both experimental groups death and acute intoxication in animals not registered, also there were no negative phenomena in behavior, reflexes were saved. Consequently, the preparation according to the degree of impact on the body of warm-blooded animals refers to low-hazard substances (4th class of hazard according to GOST 12.1.007-76). Study of the irritant action of Uritosom preparation was carried out in two series of experiments. In the first series of experiments was determined irritating action by conjunctival swab sampling method, in the second - by skin application. The study of the sensitizing action of the drug was determined by the method of maximum sensitizing effects. The authors have found that the preparation has no irritating and sensitizing effect on the tissue in its application zone. On this basis, Uritosom preparation at different ways of application is low-toxic and it can be recommended for clinical research
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