Name
Burmenskaya Galina Alekseevna
Scholastic degree
•
Academic rank
—
Honorary rank
—
Organization, job position
Kuban State Agrarian University
Web site url
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Articles count: 2
We have studied biochemical changes in the body of
cattle, sick with nodular dermatitis in the initial stage
of the clinical manifestation of the disease. It is
proved that in case of disease in animals there is a
significant increase in the level of creatinine up to
295.5 mg%. The excess of the norm by 82.1%. In
treatment, this indicator was significantly reduced (189.2 mg%), but did not reach the upper limits of the
norm (162.4 mg%). In the blood serum of patients, the
carotene content was reduced to 0.09 mg%, which
was restored to normal three days after the start of
treatment (1.0 mg%). The glucose level at the
beginning of the disease was 18% below normal and
reached the lower limit of the norm 8 hours after the
start of treatment. When studying the activity of CKK,
it was found that the activity of the enzyme in animals
before the introduction of a 5% solution of sodium
hydrogencarbonate is 82% higher than the upper limit
of the norm. After the treatment, this indicator
returned to normal. The inorganic phosphorus index
did not reach the physiological norm (2.5 mmol / l)
before and after treatment, and remained 11.6%
higher (2.9 mmol / l), which indicates a violation of
mineral metabolism in sick animals. The level of
reserve alkalinity began to recover after 8 hours of
observation and reached a minimum limit of 48.91
vol. % CO2. During the entire period of the
experimental studies, before and after the
administration of the drug, there were no significant
changes in the biochemical parameters of total
protein, calcium, vitamin E and urea. The nature of
the established changes varied within the limits of
physiological norms. The use of a 5% solution of
sodium hydrogen carbonate in nodular dermatitis
increases the effectiveness of symptomatic treatment,
reduces the likelihood of complications and stimulates
the production of specific antibodies against viruses
and bacteria. We have recommended intravenous
injection of 5% sodium hydrogencarbonate solution to
sick animals at the rate of 1 ml per 1 kg of live weight
of the animal three times with an interval of 3 days
In this study, the authors have defined the acute, subchronic and chronic toxicity of Uritosom preparation, and also its skin-irritating and sensitizing action. The studies that determined the acute toxicity of the drug Uritosom found that remedy which intended for the treatment and prevention of diseases of the genitourinary system with internal method of appointment during the entire observation period did not cause the death and acute toxicity in laboratory animals. In the study of subchronic and chronic toxicity of the drug Uritosom throughout the observation period in both experimental groups death and acute intoxication in animals not registered, also there were no negative phenomena in behavior, reflexes were saved. Consequently, the preparation according to the degree of impact on the body of warm-blooded animals refers to low-hazard substances (4th class of hazard according to GOST 12.1.007-76). Study of the irritant action of Uritosom preparation was carried out in two series of experiments. In the first series of experiments was determined irritating action by conjunctival swab sampling method, in the second - by skin application. The study of the sensitizing action of the drug was determined by the method of maximum sensitizing effects. The authors have found that the preparation has no irritating and sensitizing effect on the tissue in its application zone. On this basis, Uritosom preparation at different ways of application is low-toxic and it can be recommended for clinical research