Name
Bazaev Adlan Lechaevich
Scholastic degree
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Academic rank
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Honorary rank
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Organization, job position
Rostov Cancer Research Institute
Web site url
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Articles count: 1
The aim of the study is to compare the traditional
clinicopathologic factors and prognosis of cell cycle
parameters, such as ploidy, cell cycle kinetics, as well
as the study of DNA content in the tumor tissue of
patients with esophageal cancer. Cancer of the
esophagus - a very aggressive malignant disease, most
commonly manifested impaired swallowing. As a rule,
this type of cancer pathology is characterized by
unfavorable outcome. Ploidy and cell proliferation
activity, defined by the content of the DNA of the
tumor - synthesizing cells are one of the important
indicators of the growth rate of malignancy and
prognosis. The study was performed on tumor tissue
fragments of the 30 patients operated on for cancer of
the esophagus. DNA study - conducted in the open cell
material aftercare. DNA cell content was determined
by flow cytometry BD FACSCanto II. By studying the
DNA-cytometric parameters, we found the prevalence of aneuploid tumors in 66.7%. It was shown that DNAcytometric
parameters are independent of gender.
Major weight of diploid and aneuploid cell tumors of
the esophagus was in G0 / 1 phase of the cell cycle.
Comparative analysis of DNA - cytometric parameters
and the degree of differentiation of esophageal tumor
revealed a prevalence of aneuploid tumors in all the
test cases. content distribution pattern of tumor cells
was found in the G0 / G1-, G2 + M -, S - phase of the
cell cycle at different stages of the disease