Name
Moiseenko Tatyana Ivanovna
Scholastic degree
•
Academic rank
professor
Honorary rank
—
Organization, job position
Rostov Cancer Research Institute
Web site url
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Articles count: 2
The article analyzes the effectiveness of
plasmapheresis and xenon therapy in 40 patients with
gynecological cancer who underwent surgery in the
amount of extended panhysterectomy about cervical
cancer, who developed signs of post-castration
syndrome in the immediate postoperative period. The
content of gonadotropic pituitary hormones was
determined in the blood of patients with cervical
cancer and healthy women - follicule-stimulating,
luteinizing hormones, prolactin; steroid hormones:
estradiol, testosterone, cortisol; thyroid hormones. It is
found that xenon therapy has a more pronounced
antistress, hormone-modulating, sedative and
antidepressant effect and is more preferable to treat
post-castration syndrome. Performing of
plasmapheresis in this aspect is most justified in
patients with concomitant metabolic syndrome
Uterine cancer is the sixth on prevalence of cancer
among women in developed countries. Hyper-estrogen
level by endogenous or exogenous origin plays the
leading role in this disease pathogenesis. This study
purpose was investigating the expression of genetic
loci responsible for the estrogen reception and
metabolism to better understanding of the molecular
mechanisms of uterine tissues malignancy. We
investigated the relative expression of genes (CYP1A
1, CYP1A 2, CYP1B 1, CYP19A, ESR1, ESR2, GPER,
STS, SULT1A and SULT1E1) by real-time PCR in
tumor and conditionally healthy uterine tissues of 27
female patients in Southern Russia aged 38-72 years
with histologically confirmed diagnosis of uterine
cancer. It is found that transcription activity of these
genes during malignancy of uterine tissues depends of
female patients age and the stage of tumor cells
differentiation. It is found that malignancy change in
the transcriptional activity of investigated genes in
uterine tissue depends of patients age and stage of
tumor cells differentiation. Particularly, it was found,
that changes of gene transcription balance of enzymes
that provide sulfation and hydrolysis of steroid sulfates is depending of patient age and the degree of tumor
cells differentiation. In addition, the sinking of gene
expression of nuclear estrogen receptor ESR1 as
lowering cell differentiation of tumor tissues. We have
also shown gene expression of nuclear estrogen
receptor ESR1 decline as lowering cell differentiation
of tumor tissues