Scientific Journal of KubSAU

Polythematic online scientific journal
of Kuban State Agrarian University
ISSN 1990-4665
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Name

Zotova Tatiana Aleksandrovna

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Honorary rank

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Krasnodar Scientific Research Institute of Veterinary
   

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tanja_z@list.ru


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THEORETICAL AND EXPERIMENTAL BASIS FOR THE USE OF INJECTION HEPATOPROTECTORS IN THE PROPHYLACTICS OF LIVER DISEASES IN COWS

abstract 1321708027 issue 132 pp. 335 – 345 31.10.2017 ru 130
The use of intensive milk production technologies in practice, nonobservance of the principles of feeding and keeping animals leads to a decrease in the level of compensatory-regenerative processes in the body, violation of general and specific metabolic reactions, emergence of a number of pathological conditions, and, primarily, hepatopathies leading to a decrease in the productivity of dairy cattle, to the birth of unviable young animals and to the impossibility of their further exploitation. Therefore, on the background of early diagnosis of violations of the liver it is necessary to conduct adequate pharmacoprophylaxis, which prevents further development of hepatopathies with the help of hepatoprotectors. These preparations include a new injectable one – livazen, the mechanism of action of which works due to its antioxidant and membrane-stabilizing action. The preparation has a lipotropic effect, favorably affects the antitoxic and pigmentary function of liver, and increases resistance to hypoxia and various kinds of intoxication. Research conducted to study its effect in the system of prophylactic measures of hepatosis in sterile cows showed that on the background of the use of lavazen there was a significant increase in total protein by 16,6% and increase in albumins - by 13,8%. The level of γ-globulins, on the contrary, decreased by 20,9%. The study of the preparation had a normalizing effect on lipid metabolism, which was manifested by an increase in the concentration of triglycerides in 3,1 times and increase in cholesterol by 24,7%. An increase in the concentration of calcium by 14,5% was also found out. The use of livazen allowed to ensure a tendency towards a decrease in enzyme activity (according to AST - by 6,9%, by ALT - by 24,4%, according to alkaline phosphatase - by 11,6%), in contrast to control animals whose aspartate aminotransferase increased by 11,3% from the initial; ultrasonography of liver of cows confirmed the expressed effectiveness of the pharmacoprophylaxis
.