Scientific Journal of KubSAU

Polythematic online scientific journal
of Kuban State Agrarian University
ISSN 1990-4665
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Kuzminova Elena Vasilevna

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GNU Krasnodar NIVI

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Articles count: 8

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abstract 1291705080 issue 129 pp. 1113 – 1125 31.05.2017 ru 337
Carotenoid preparations are quite widely used in a health care, but in the veterinary and animal husbandry, their use is limited. In terms of livestock farms of the Krasnodar region and the Rostov region at the biochemical monitoring studies of the cattle blood the lack of carotene in the serum is revealed from 45 to 100 % of the samples. To study the biological function of carotenoid we used preparations, which are the oily solutions for injections: β-carotene (manufactured by FS 42-3867, which is produced from the biomass culture of the fungus Blakeslea trispora) and lycopene, emitted from plants. The cows in the test groups during the dry period and within two weeks after birth got carotenoid preparation subcutaneously at a dose of 10 ml per animal with an interval of 7 days. As a result, it was found out that the application of carotenoids has the most favorable conditions for the flow of labor and the postnatal period, which are manifested in the decrease in obstetric and gynecological diseases in cows and reduce the period of infertility. In the experimental groups the levels of vitamin A and carotene1,3 times higher (1,26 ± 0,14 μmol/L vs. 0,97 ± 0,09 μmol/L ) 1,8 times (0,34 ± 0 03 mg /% vs. 0.61 ± 0.11 mg /%) respectively in comparison with the parameters of the intact animals at a high level of confidence (P < 0,05). Phagocytic number and percentage of digestion of neutrophils increased by 8,5 %, the difference in the number of B-cells reached 9,1%, T-cells – 6,7%. In a humoral immunity found a significant increase in Ig A. After comparison of the level of lysozyme activity of blood serum was observed its reduction in all animals immediately after birth, but in the experimental groups this process was less pronounced. The use of carotene preparations helps to reduce the concentration of lipid peroxidation products in the body of cows (diene conjugates - by 16,6 %, ketodienes - by 35,7 %, malondialdehyde – by 11,3 %), which creates favorable conditions for the flow of the metabolic processes associated with ensuring the normal childbirth and post-partum involution of the genitals. In the group of cows, receiving the carotenoid lycopene, the dyspepsia morbidity of the newborn calves compared to a control decreased by 26,7 %, bronchopneumonia - by 13,3 %
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abstract 1191605076 issue 119 pp. 1077 – 1088 31.05.2016 ru 267
This article presents the results of the studies of the influence of a new complex hepatoprotective preparation on the basic system of the body, the mechanism of occurrence and manifestation of its biological effects, the dependence of this action from the components that are parts of the preparation, the dose, as well as the regularity of manifestation of possible side effects. The effect of the different doses of the preparation (1% and 2%) on the average daily weight gain and morphological and biochemical indices of the birds’ blood was studied. The conducted research determined a stimulatory influence of the preparation on the growth, development and safety of broiler chickens. The new hepatoprotector exhibits the properties aimed on revitalizing the erythro- and hematopoiesis and magnification of the cellular immunity against the exogenous influence. The use of the preparation helps to improve liver function and reduce the toxic load on hepatocytes, which manifests an increase in a number of metabolic parameters, such as total protein, glucose, calcium, phosphorus. We have noted an expressed hepatoprotective effect on the enzyme activity of AST and the remission of the cytolytic syndrome of the experimental chickens. Thereby it was found out that the complex hepatoprotective preparation has a pronounced pharmacological activity, providing a significant impact on the energy of the broiler chickens’ growth and their safety, morphological and biochemical indices of the blood and metabolic processes in the body of the bird
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abstract 0701106043 issue 70 pp. 608 – 617 30.06.2011 ru 1581
In the article, the effects of approbation of complex therapy are resulted at oligotrophy of calves with use of the preparation of protein hydrolysis and Dipromo-nium - M. The antihypotrophic action of preparations and efficiency of the scheme for augmentation of additional weights of calves and optimization of bio-chemical profile of blood are established
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abstract 1061502043 issue 106 pp. 688 – 699 28.02.2015 ru 505
An accelerated growth of farm animals in order to obtain maximum productivity is possible due to introduction stimulating additives and preparations based on them into the rations. One of such tools is Polisilar - complex preparation, which includes components that have a positive impact on various aspects of the animal metabolism in the conditions of physiological disorders. At the same time components of the preparation due to its high bioavailability exhibit a potentiating effect in the body that allows getting a more pronounced effect on its use. Studies were conducted on pigs 3-3.5 months age and showed that the Polisilar preparation has a positive effect on the clinical and physiological status of the animals and exhibits a pronounced growth stimulating effect, increasing the weight gain of pigs by 14.3%. In addition use of the preparation in rations of growing pigs has a normalizing effect on red blood and blood forming organs, increasing the number of red blood cells by 18.7%, hemoglobin - by 24.5%. Polisilar stimulates protein, carbohydrate and mineral exchanges, stabilizes the functional activity of the liver, reducing the toxic load on hepatocytes. Therefore, the preparation Polisilar has a pronounced biological and pharmacological activity and can be used in animal husbandry as an effective stimulant
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abstract 1021408048 issue 102 pp. 779 – 789 31.10.2014 ru 845
This article presents the results of preclinical study of the pharmacological properties of a new medicine composed of phospholipids and antioxidants. It is found that the medicine called Gepavitol in experimental damage of the liver of laboratory rats shows some hepatoprotective effects
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abstract 1321708027 issue 132 pp. 335 – 345 31.10.2017 ru 543
The use of intensive milk production technologies in practice, nonobservance of the principles of feeding and keeping animals leads to a decrease in the level of compensatory-regenerative processes in the body, violation of general and specific metabolic reactions, emergence of a number of pathological conditions, and, primarily, hepatopathies leading to a decrease in the productivity of dairy cattle, to the birth of unviable young animals and to the impossibility of their further exploitation. Therefore, on the background of early diagnosis of violations of the liver it is necessary to conduct adequate pharmacoprophylaxis, which prevents further development of hepatopathies with the help of hepatoprotectors. These preparations include a new injectable one – livazen, the mechanism of action of which works due to its antioxidant and membrane-stabilizing action. The preparation has a lipotropic effect, favorably affects the antitoxic and pigmentary function of liver, and increases resistance to hypoxia and various kinds of intoxication. Research conducted to study its effect in the system of prophylactic measures of hepatosis in sterile cows showed that on the background of the use of lavazen there was a significant increase in total protein by 16,6% and increase in albumins - by 13,8%. The level of γ-globulins, on the contrary, decreased by 20,9%. The study of the preparation had a normalizing effect on lipid metabolism, which was manifested by an increase in the concentration of triglycerides in 3,1 times and increase in cholesterol by 24,7%. An increase in the concentration of calcium by 14,5% was also found out. The use of livazen allowed to ensure a tendency towards a decrease in enzyme activity (according to AST - by 6,9%, by ALT - by 24,4%, according to alkaline phosphatase - by 11,6%), in contrast to control animals whose aspartate aminotransferase increased by 11,3% from the initial; ultrasonography of liver of cows confirmed the expressed effectiveness of the pharmacoprophylaxis