Acceptable values of the drainage hole parameters in the shunt glaucoma surgery were calculated by means of mathematical modeling of different conditions of eye hydrodynamics. The operation method was designed with provision for pressure gradient, rate of the aqueous humor outflow, and the values of intraocular pressure in early and late postoperative period. The balance of liquid in eye was calculated in mathematical model as ordinary differential equation in accordance with flow resistance of every section. The data received by using mathematical model has shown that allowable rate of aqueous humor outflow is gained with the hole diameter of 0,025 mm. This mathematical model should assist to the better understanding of physical processes describing the eye hydrodynamics, should benefit to the operation quality and should create the base to the clinical studies
The aim of the research was to assess the effect of nondrug
correction of urogenital disorders in female
patients with metabolic syndrome during the
menopause. The research includes 330 women aged
45-50 with metabolic syndrome. Three equal groups
with 110 female patients each were formed: the main
group, the first control group, and the second control
group. In the main group, the non-drug treatment (diet
therapy, psychotherapy, physical therapy, exercise
therapy) and the vitamin-mineral treatment were
combined. In the first control group, only non-drug
treatment was used. In the second control group, only
the vitamin-mineral treatment was used. Before the
treatment and in six months after the treatment, the
following was assessed: the intensity of vaginal
atrophy symptoms according to the 5-point Barlow
scale; Bochman vaginal health index; urinary diaries
data. The results of the research showed: the average
value of Bochmanvaginal health index has most
significantly increased in the main group (from
3,64±0,63 pointsto 4,67±0,68 points, p
This article presents the results of regulation adaptive status when decreasing kidneys filtration capacity
Recently, much attention is paid to research the role of cell-cell interactions by gap junctions in the process of malignant transformation and mechanisms of antitumor resistance. Meanwhile, the greatest interest is astrocytic tumors. Depending on the degree of malignancy, astrocytomas are divided into: pilocytic astrocytoma (Grade I), subependymal giant cell astrocytoma (Grade I), pleomorphic xanthoastrocytoma (Grade II), diffuse astrocytoma (Grade II), anaplastic astrocytoma (Grade III), glioblastoma (Grade IV ) gliomatosis cerebri (Grade IV). Information of literature devoted to astrocytic tumors (gliomas) - the most common brain tumor in large part obtained in studies in cell cultures and different contradictions. Along with data on the reduction of glial tumors cells communicability through GJ, there is evidence of an opposite character - a functionally active GJ in gliomas and inhibition of tumor growth by reducing intercellular communicability by GJ. However, up to now there have been no studies of the effect and function of hemichannels in cancer cells, which would provide detailed information on: 1) the characteristic of presence and relative abundance of hemichannels in cancer cells; 2) evaluation of absorption / release of hemichannels mediated molecules in tumor cells than in non-tumor cells; 3) functional consequences of activation and blocking of hemichannels in tumor cells and 4) the prognostic value of the expression / activation of hemichannels in human malignancies
Comparative analysis of the informativity of ultrasonic
and radiographic examination of the lungs at the initial
diagnosis of inflammatory infiltrate and at case followup
of its involution during treatment was performed in
154 children with pneumonia. Higher informativity of
ultrasound compared with radiography was
determined. All children underwent ultrasound
monitoring of pneumonia since admission to the full
restoration of normal ultrasound image. Assessment
criteria of pneumonia involution were the size and
echostructure of an airless zone. Stationary ultrasound
was performed at least 3 times. Outpatient ultrasound
was repeated at least 2 times within 1 month, in some
cases children were observed up to 3 months with
monthly dualfold study
In the article we have presented the evaluation of the
cardiopulmonary synchronism test possible use for the
differential diagnosis of the sick sinus syndrome of
functional and organic origin in children
The dramatic lowering of intraocular pressure (hypotony) is developing during glaucomatous surgery due to the formation of the new aqueous humor outflow. The calculations of the flow in the fluid balance parameters have shown, that for the normal intraocular pressure maintenance in the postoperative period the fluid flow out of the anterior chamber should not exceed 0,04 microliter in minute. The intensity of the aqueous humor outflow through the shunts with different parameters does not depend on the shunt length. The shunt with the inner hole radius 0,025 mm is the most safe as it provide the less outflow. The experimental comparative study of the static viscosity of the most widely used viscoelastics in ophthalmological surgery was carried out. It was stated that used in eye surgery viscoelastics on the basis of 1%, 2% and 3% sodium hyaluronate possess the viscosity, that differs in 10 and 100 times and has significant influence on the flow intensity out of the anterior chamber when the new outflow tracts are formed. The mathematically based choice of the most optimal relationship between the viscoelastics physical parameters and the inner hole size of the shunt type glaucoma drainage devices was established. Shunt with the inner hole radius 0,05 mm and simultaneous use of 2% and 3% sodium hyaluronate solution is the most safe for the maintenance of the eye tonus during the first 5 days after glaucoma surgery. The presented correlation allows to increase the safety of the surgical treatment of the patients with the refractory glaucoma
Study was performed on 12 samples of astrocytic human brain tumors, which differ by the level of malignancy and histological indications. The study was conducted with the method of immunohistochemistry using a commercially available antibody anti-connexin-43 (Cx 43), a prior test of
which was carried out on myocardium tissue of rats (positive control). The study showed that with the increasing of malignant level of astrocytomas, there was marked the decreased level of connexin-43 expression of, which is apparently to be associated with the destruction of intercellular gap junctions in tumor tissue
The study included 245 patients from 60 to 89 years, comparable by age and sex, were divided into two groups according to region of residence (Arctic and Antarctic), for two age groups (elderly and senile age) and by the sex. The main method of the study of cerebral hemodynamics in this work has been ultrasound dopplerography (usdg). Doppler sonography survey with color scanning and spectral Doppler analysis of the cervical arteries on extracranial level was performed according to standard method for ultrasound systems ACUSON “Sequoia-512” sensor linear format of the generated frequency of the ultrasonic signal 4 and 8 MHz in the ever-wave mode. The entire sample investigated the functional state of the kidneys. GFR was determined by the settlement formulas; Cockcroft&Gault GFR= (140-age) × body weight (kg) 810* creatinine of blood (mol/l)×E, where E-1,23 for men, 1,04-for women and MDRD: GFR= 186×(creatinine of blood mg/dd)-1,154 × (age)-0,203 × (0,742 for women) with subsequent determination of the stages of chronic kidney disease. We used a brief MDRD formula, which of laboratory indicators requires only establishing the values of concentrations of serum creatinine
The retrospective study of patients with retinal vein
occlusion and frequency of pseudoexfoliation
syndrome is made in this study. Retinal vein occlusion
is the second most common type of retinal vascular
disorder, after diabetic retinal disease, and may
develop with a consequent reduction in visual acuity.
Pseudoexfoliation syndrome is an age-related disease
characterized by the production and accumulation of a
fibrillar extracellular material in several ocular tissues
We have analyzed data of 73 patients with retinal vein
occlusion. It was detected that risk of central vein
occlusion is higher in patients with pseudoexfoliation
syndrome (23,3% of patients were diagnosed as having
pseudoexfoliation syndrome). In the branch retinal
vein occlusion group only 9,3% of patients had
pseudoexfoliation syndrome. In control group only
8,6% of patients had this syndrome. Control group was
made of 80 patients similar in age without any retinal
and cardiovascular abnormalities, patients with
episodes of ocular hypertension, glaucoma, and those
who had undergone cataract surgery were excluded
from the study. Pseudoexfoliation syndrome may be
considered as an independent risk factor for
development of central retinal vein occlusion