Name
Novikova Inna Arnol’dovna
Scholastic degree
•
Academic rank
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Honorary rank
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Organization, job position
Rostov Cancer Research Institute
Web site url
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Articles count: 4
While studying the content of hypoxia-inducible factor
1-alpha and vascular endothelial growth factor in the
tumor tissue, oral fluid and peripheral blood of 141
patients with oral mucosa cancer T1-3N0-2M0, it was
shown that the development of purulent inflammatory
postoperative complications in patients with oral
mucosa cancer is associated with an increased
expression of HIF-1α in the tissue and its translocation
from the cytoplasm to the nucleus, activation of the
neoangiogenesis processes. It is informative to
determine HIF-1α factor in the blood serum, which,
for further development, can be used as a non-invasive
diagnostic marker to predict the postoperative course
in this category of patients
A retrospective immunohistochemical study of lymphocyte and macrophage infiltration in tumor tissue of 84 vulvar cancer patients with a long (over 2 years) and short (less than 2 years) remission was performed to determine a possible role of immunologic microenvironment of tumors in maintaining remission. Vulvar cancer patients with a short remission period were aged 46-85 years, mean age 67 years. 15.8% of them had stage I of the disease, 21% - stage II, 47.4% - stage III and 15.8% - stage IV. The average duration of remission in this group was 11 months. Patients with a long remission period were aged 27-71 years, mean age 48 years. 38.5% of them had stage I of the disease, 53.8% - stage II and 7.7% - stage III. The average duration of remission in this group was 8 years. Histological study showed squamous cell carcinoma in all patients. Stroma and parenchyma of tumor tissues demonstrated lymphocyte and macrophage infiltration of various degrees with the predominance of T-lymphocytes. CD8+ cells prevailed in tumor tissue of patients with a long remission period (over 2 years), while a higher level of CD4+ Т-lymphocytic infiltration was associated with a short remission (less than 2 years) and a poor prognosis. These differences allow prediction of the vulvar cancer course and its early or late recurrence
The aim of the study is to compare the traditional
clinicopathologic factors and prognosis of cell cycle
parameters, such as ploidy, cell cycle kinetics, as well
as the study of DNA content in the tumor tissue of
patients with esophageal cancer. Cancer of the
esophagus - a very aggressive malignant disease, most
commonly manifested impaired swallowing. As a rule,
this type of cancer pathology is characterized by
unfavorable outcome. Ploidy and cell proliferation
activity, defined by the content of the DNA of the
tumor - synthesizing cells are one of the important
indicators of the growth rate of malignancy and
prognosis. The study was performed on tumor tissue
fragments of the 30 patients operated on for cancer of
the esophagus. DNA study - conducted in the open cell
material aftercare. DNA cell content was determined
by flow cytometry BD FACSCanto II. By studying the
DNA-cytometric parameters, we found the prevalence of aneuploid tumors in 66.7%. It was shown that DNAcytometric
parameters are independent of gender.
Major weight of diploid and aneuploid cell tumors of
the esophagus was in G0 / 1 phase of the cell cycle.
Comparative analysis of DNA - cytometric parameters
and the degree of differentiation of esophageal tumor
revealed a prevalence of aneuploid tumors in all the
test cases. content distribution pattern of tumor cells
was found in the G0 / G1-, G2 + M -, S - phase of the
cell cycle at different stages of the disease
Mortality from malignant diseases is directly linked to
early metastasis and relapse. It is now possible to
identify individual tumor cells in bone marrow
biopsies and peripheral blood. Colorectal cancer is one
of the leading places in the structure of cancer
incidence and mortality, both in Russia and around the
world. Studies have shown that after surgery the ability
of tumor cells to the dissemination and implantation
increases. The work contains 30 patients with the
verified colorectal cancer with metastasis to the liver.
To determine the CSC we have applied an analysis
technology in CellSearch System â„¢ (Janssen
Diagnostics, LLC). Our study of the number and
frequency of detection of circulating tumor cells in
peripheral blood of patients and control group
demonstrates the reduction in the number of CTCs
during laparoscopic surgery and changing the
dynamics of the level of tumor cells in the form of
reduction from the stage of the mobilization of the drug due to minimally invasive access, minimizing
manipulation in the projection of the tumor and as a
consequence, preventing the release into the blood
stream of single tumor cells